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[Signs and symptoms of ocular surface disease in patients on topical intraocular pressure-lowering therapy].
- Source :
-
Arquivos brasileiros de oftalmologia [Arq Bras Oftalmol] 2013 Oct; Vol. 76 (5), pp. 282-7. - Publication Year :
- 2013
-
Abstract
- Purpose: To determine the prevalence of signs and symptoms of ocular surface disease (OSD) in patients using topical intraocular pressure-lowering therapy.<br />Methods: In this cross-sectional study, 40 patients were consecutively recruited from the glaucoma clinic of a public hospital located in Rio de Janeiro, Brazil. Eligible patients were 18 years of age or older, with primary open-angle glaucoma or ocular hypertension and on the same topical ocular therapy for at least 6 months. The following data were considered: sex, age, medication history and number of years on topical intraocular pressure-lowering therapy. All patients underwent an evaluation of the ocular surface which included: an interview using the Ocular Surface Disease Index® (OSDI®) questionnaire, break-up time, biomicroscopy, fluorescein corneal staining and rose Bengal ocular surface staining.<br />Results: The mean OSDI® score was 24.6 ± 20.7. Most patients (67.5%) had an abnormal score on the OSDI® questionnaire. In 25% of patients, the score was consistent with mild symptoms, 12.5% with moderate symptoms and 30% with severe symptoms. Blepharitis and punctate keratitis were diagnosed in 42.5% and 20% of patients respectively. Tear film instability was observed in 75% of patients and ocular surface staining with rose Bengal in 35%. A positive statistically significant correlation (r=0.4; p=0.01) was found between OSDI® scores and the duration of topical intraocular pressure-lowering therapy.<br />Conclusion: Patients with primary open-angle glaucoma or ocular hypertension on topical intraocular pressure-lowering therapy have high prevalence of OSD. Longer duration since diagnosis is significantly correlated with worsening of OSD symptoms.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Blepharitis diagnosis
Cornea drug effects
Cross-Sectional Studies
Female
Fluorescein
Glaucoma, Open-Angle prevention & control
Humans
Keratitis diagnosis
Lacrimal Apparatus Diseases diagnosis
Male
Microscopy, Acoustic methods
Middle Aged
Severity of Illness Index
Surveys and Questionnaires
Young Adult
Antihypertensive Agents therapeutic use
Intraocular Pressure drug effects
Ocular Hypertension drug therapy
Sulfonamides therapeutic use
Thiophenes therapeutic use
Timolol therapeutic use
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 1678-2925
- Volume :
- 76
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Arquivos brasileiros de oftalmologia
- Publication Type :
- Academic Journal
- Accession number :
- 24232941
- Full Text :
- https://doi.org/10.1590/s0004-27492013000500006