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KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2013 Dec; Vol. 149 (3), pp. 498-508. Date of Electronic Publication: 2013 Sep 25. - Publication Year :
- 2013
-
Abstract
- KIR2DS4 is the only activating gene within the A haplotype, and alleles of KIR2DS4 can encode either functional (KIR2DS4-f) or non-functional (KIR2DS4-v) variants. To establish the role of KIR2DS4 in the context of HIV-1 mother-to-child transmission, we KIR genotyped 145 HIV-1 non-transmitting mothers (NT) and their exposed uninfected infants (EU), and 72 HIV-1 transmitting mothers (TR) and their infected infants [intrapartum (IP), in utero (IU) or IU2 (an IU-enriched infected group)]. The frequency of KIR2DS4-v was significantly higher in IU2 infants compared to EU infants (P=0.022, OR=2.88); this association was more significant amongst AA haplotypes (P=0.004, OR=18.4). Possession of KIR2DS4-f in the mother with absence in the infant (M+I- discordance) was associated with a higher risk of IP transmission (P=0.005, OR=3.84); whilst in M-I+ discordance, infant possession of KIR2DS4-v was associated with increased risk of IU acquisition (P=0.002; OR=6.40). This study highlights the importance of KIR2DS4 in HIV-1 transmission/acquisition.<br /> (© 2013.)
- Subjects :
- Adult
Alleles
Female
Gene Frequency
HIV Infections immunology
HIV Infections virology
Haplotypes
Humans
Infant
Male
Protein Isoforms genetics
Protein Isoforms immunology
Receptors, KIR immunology
Risk
Viral Load
HIV Infections genetics
HIV Infections transmission
HIV-1
Infectious Disease Transmission, Vertical
Receptors, KIR genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 149
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 24239756
- Full Text :
- https://doi.org/10.1016/j.clim.2013.09.005