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Network medicine in disease analysis and therapeutics.

Authors :
Chen B
Butte AJ
Source :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2013 Dec; Vol. 94 (6), pp. 627-9.
Publication Year :
2013

Abstract

Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom-based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends.

Details

Language :
English
ISSN :
1532-6535
Volume :
94
Issue :
6
Database :
MEDLINE
Journal :
Clinical pharmacology and therapeutics
Publication Type :
Academic Journal
Accession number :
24241637
Full Text :
https://doi.org/10.1038/clpt.2013.181