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[Expression of Six1 and Six4 in esophageal squamous cell carcinoma and their correlation with clinical prognosis].
- Source :
-
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2013 Jul; Vol. 42 (7), pp. 446-50. - Publication Year :
- 2013
-
Abstract
- Objective: Six1 and Six4 are expressed in several tumors, and associated with tumor progress and poor prognosis. The aim of this study was to investigate the expression of Six1 and Six4 in esophageal squamous cell carcinoma (ESCC), and to evaluate their correlation with the clinicopathological factors and prognosis.<br />Methods: Tissue microarray technology and immunohistochemical method (EnVision) were used to detect the expression of Six1 and Six4 in the tumor tissues and corresponding adjacent normal epithelium of esophagus from 292 ESCC patients.<br />Results: Among the 292 ESCC patients, the positive rates of Six1 and Six4 protein expression in tumor tissues were 72.9% (213/292) and 56.2% (164/292), respectively, significantly higher than the expression rate of 33.2% (97/292) and 32.5% (95/292) in adjacent normal epithelium of esophagus (P < 0.05). Chi square test showed that the expression of Six1 protein was related to tumor size, depth of tumor invasion and patient survival status; higher Six4 protein expression level was related to poor differentiation and increased depth of invasion. Single factor Log-rank analysis revealed that gender, TNM stage, Six1 protein expression level were related to the overall survival of ESCC patients (P < 0.05), while the five-year survival rate was significantly higher in the Six1-negative group than the Six1-positive group [51.9% (41/79) vs. 43.7% (93/213)]. Multi-factor Cox proportional risk model analysis showed that TNM stage and positive expression of Six1 were independent prognostic factors for ESCC patients (P < 0.05).<br />Conclusions: Six1 and Six4 are highly expressed in ESCC. Their expression levels are closely related to the progress and prognosis of ESCC. Over-expression of Six1 is related to poor prognosis in ESCC patients. Thus, Six1 could be used as an important prognostic indicator for ESCC patients.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell surgery
Esophageal Neoplasms surgery
Esophageal Squamous Cell Carcinoma
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Proportional Hazards Models
Risk Factors
Survival Rate
Tumor Burden
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Esophageal Neoplasms metabolism
Esophageal Neoplasms pathology
Homeodomain Proteins metabolism
Trans-Activators metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0529-5807
- Volume :
- 42
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhonghua bing li xue za zhi = Chinese journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24246862
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0529-5807.2013.07.004