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Collagen-derived peptides release mast cell histamine.

Authors :
Wize J
Wojtecka-Lukasik E
Maśliński S
Source :
Agents and actions [Agents Actions] 1986 Apr; Vol. 18 (1-2), pp. 262-5.
Publication Year :
1986

Abstract

The effect of collagen degradation products by bacterial (BCDP) and synovial fluid collagenase (SCDP) on histamine release from peritoneal mast cells of rat was estimated. Some BCDP as well as SCDP released 60-80% of mast cell histamine. In BCDP fraction the most active were BCDP II (m.wt. 13 kD) and BCDP III (m.wt. 6 kD). The last contained the highest percentage of hydroxyproline. As compared with bradykinin, BCDP III was about 50 fold more active as histamine releaser.

Subjects

Subjects :
Animals
Bacteria metabolism
Connective Tissue Diseases etiology
In Vitro Techniques
Male
Microbial Collagenase pharmacology
Peptides pharmacology
Rats
Rats, Inbred Strains
Synovial Fluid enzymology
Collagen metabolism
Histamine Release drug effects
Mast Cells metabolism

Details

Language :
English
ISSN :
0065-4299
Volume :
18
Issue :
1-2
Database :
MEDLINE
Journal :
Agents and actions
Publication Type :
Academic Journal
Accession number :
2425589
Full Text :
https://doi.org/10.1007/BF01988037
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