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Higher quality quercetin sustained release ethyl cellulose nanofibers fabricated using a spinneret with a Teflon nozzle.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2014 Feb 01; Vol. 114, pp. 404-9. Date of Electronic Publication: 2013 Nov 01. - Publication Year :
- 2014
-
Abstract
- This study investigates the usage of a spinneret with a Teflon nozzle for fabrication of higher quality drug sustained-release electrospun nanofibers. Ethyl cellulose (EC) and quercetin were used as a filament-forming polymer matrix and an active pharmaceutical ingredient, respectively. The electrospinning was conducted using both a traditional stainless steel spinneret and a spinneret with a Teflon nozzle. Experimental results demonstrated that a Teflon-fluid interface at the spinneret's nozzle provided a better performance for implementing electrospinning than a traditional metal-fluid interface in the following aspects: (1) keeping more electrical energy on the working fluids for an efficacious process; (2) exerting less negative effect on the fluid to draw it back to the tube; and (3) making less possibility of clogging. The resulted nanofibers from the spinneret with a Teflon nozzle exhibited higher quality than those from the traditional spinneret in those: (1) smaller diameter and narrower distribution, 520±70 nm for the former and 750±280 nm for the later, as indicated by the field emission scanning electron microscopic images; and (2) better sustained-release profiles of quercetin from the former than the latter, as demonstrated by the in vitro dissolution tests. The new protocols about usage of Teflon as a spinneret's nozzle and the related knowledge disclosed here should promote the preparation and application of electrospun functional nanofibers.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Cellulose chemistry
Delayed-Action Preparations
Energy Transfer
Nanofibers ultrastructure
Particle Size
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Cellulose analogs & derivatives
Drug Delivery Systems instrumentation
Drug Delivery Systems methods
Nanofibers chemistry
Polytetrafluoroethylene chemistry
Quercetin administration & dosage
Quercetin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 114
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 24257689
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2013.10.040