Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate.

Authors :: Fiume L
Bassi B
Busi C
Mattioli A
Spinosa G
Faulstich H
Source :: FEBS letters [FEBS Lett] 1986 Jul 28; Vol. 203 (2), pp. 203-6.
Publication Year :: 1986
Abstract: D-Galactopyranosyl residues were coupled to poly(L-lysine) and the antiviral agents arabinofuranosyladenine 5'-monophosphate (ara-AMP) and acyclovir were conjugated with this glycosylated polymer. In mice the ara-AMP conjugate accomplished a selective drug delivery to liver cells.

Subjects :: Acyclovir administration & dosage
Acyclovir analogs & derivatives
Animals
DNA biosynthesis
Mice
Pharmaceutical Vehicles
Serum Albumin administration & dosage
Vidarabine Phosphate metabolism
Arabinonucleotides administration & dosage
Galactose administration & dosage
Liver metabolism
Polylysine administration & dosage
Vidarabine Phosphate administration & dosage

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