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FVIII/VWF ratio is not a reliable predictor of VWD in children.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2014 May; Vol. 61 (5), pp. 936-9. Date of Electronic Publication: 2013 Nov 26. - Publication Year :
- 2014
-
Abstract
- Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold-based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population.<br /> (© 2013 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Blood Coagulation Tests
Case-Control Studies
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Infant
Male
Middle Aged
Prognosis
Young Adult
von Willebrand Disease, Type 1 blood
Biomarkers blood
Factor VIII analysis
von Willebrand Disease, Type 1 diagnosis
von Willebrand Factor analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 61
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 24281894
- Full Text :
- https://doi.org/10.1002/pbc.24860