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Latest status of the clinical and industrial applications of cell sheet engineering and regenerative medicine.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2014 Jan; Vol. 37 (1), pp. 96-106. Date of Electronic Publication: 2013 Nov 30. - Publication Year :
- 2014
-
Abstract
- Cell sheet engineering, which allows tissue engineering to be realized without the use of biodegradable scaffolds as an original approach, using a temperature-responsive intelligent surface, has been applied in regenerative medicine for various tissues, and a number of clinical studies have been already performed for life-threatening diseases. By using the results and findings obtained from the initial clinical studies, additional investigative clinical studies in several tissues with cell sheet engineering are currently in preparation stage. For treating many patients effectively by cell sheet engineering, an automated system integrating cell culture, cell-sheet fabrication, and layering is essential, and the system should include an advanced three-dimensional suspension cell culture system and an in vitro bioreactor system to scale up the production of cultured cells and fabricate thicker vascularized tissues. In this paper, cell sheet engineering, its clinical application, and further the authors' challenge to develop innovative cell culture systems under newly legislated regulatory platform in Japan are summarized and discussed.
- Subjects :
- Animals
Cell Differentiation
Cell Proliferation
Cells, Cultured
Government Regulation
Health Policy
Humans
Polymers chemistry
Regenerative Medicine legislation & jurisprudence
Stem Cell Transplantation
Cell Culture Techniques
Regenerative Medicine methods
Stem Cells physiology
Tissue Engineering legislation & jurisprudence
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 24293063
- Full Text :
- https://doi.org/10.1007/s12272-013-0299-8