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In-vitro assessment and pharmacodynamics of nimesulide incorporated Aloe vera transemulgel.
- Source :
-
Current drug discovery technologies [Curr Drug Discov Technol] 2014 Jun; Vol. 11 (2), pp. 162-7. - Publication Year :
- 2014
-
Abstract
- The aim of the investigation was to prepare nimesulide emulsion for incorporation in Aloe vera gel base to formulate 'nimesulide - Aloe vera transemulgel' (NAE) and to carryout in-vitro assessment and in-vivo anti-inflammatory studies of the product. Although the use of nimesulide is banned for oral administration, due to its potential for inducing hepatotoxicity and thrombocytopenia, the use of nimesulide for topical delivery is prominent in the treatment of many inflammatory conditions including rheumatoid arthritis. The drug loading capacity of transdermal gels is low for hydrophobic drugs such as nimesulide. Nimesulide can be effectively incorporated into emulgels (a combination of emulsion and gel). Aloe vera has a mild anti-inflammatory effect and in the present study Aloe vera gel was formulated and used as a gel base to prepare NAE. The emulgels thus prepared were evaluated for viscosity, pH, in-vitro permeation, stability and skin irritation test. In-vivo anti-inflammatory studies were performed using carrageenan induced hind paw edema method in Wistar rats. The results were compared with that of commercial nimesulide gel (CNG). From the in-vitro studies, effective permeation of nimesulide from NAE (53.04 %) was observed compared to CNG (44.72 %) at 30 min indicating better drug release from NAE. Topical application of the emulgel found no skin irritation. Stability studies proved the integrity of the formulation. The percentage of inhibition of edema was highest for the prepared NAE (67.4 % inhibition after 240 min) compared to CNG (59.6 %). From our results, it was concluded that the Aloe vera gel acts as an effective gel base to prepare nimesulide emulgel with high drug loading capacity (86.4 % drug content) compared to CNG (70.5 % drug content) with significant anti-inflammatory effect.
- Subjects :
- Aloe
Animals
Carrageenan
Drug Stability
Edema chemically induced
Edema drug therapy
Gels
Hydrogen-Ion Concentration
Male
Rats, Wistar
Skin drug effects
Viscosity
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Plant Preparations chemistry
Plant Preparations pharmacology
Plant Preparations therapeutic use
Sulfonamides chemistry
Sulfonamides pharmacology
Sulfonamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6220
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current drug discovery technologies
- Publication Type :
- Academic Journal
- Accession number :
- 24295369
- Full Text :
- https://doi.org/10.2174/1570163810666131202233721