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Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with (1)H MRS.
- Source :
-
Magma (New York, N.Y.) [MAGMA] 2014 Oct; Vol. 27 (5), pp. 397-405. Date of Electronic Publication: 2013 Dec 04. - Publication Year :
- 2014
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Abstract
- Objects: Hepatic and pancreatic fat content become increasingly important for phenotyping of individuals with metabolic diseases. This study aimed to (1) evaluate hepatic fat fractions (HFF) and pancreatic fat fractions (PFF) using (1)H magnetic resonance spectroscopy (MRS) and the recently introduced fast mDixon method, and to examine body fat effects on HFF and PFF, (2) investigate regional differences in HFF and PFF by mDixon.<br />Materials and Methods: HFF and PFF were quantified by mDixon with two flexible echo times and by single voxel (1)H MRS in 24 healthy subjects. The regional differences of PFF within the pancreas were assessed with mDixon. Abdominal visceral and subcutaneous fat was assessed by T1-weighted MRI at 3T.<br />Results: Both methods correlated well for quantification of HFF (r = 0.98, p < 0.0001) and PFF (r = 0.80, p < 0.0001). However, mDixon showed a higher low limit in HFF and PFF. PFF showed no regional differences using mDixon. In addition, both visceral and subcutaneous fat correlated with pancreatic fat, while only visceral fat correlated with liver fat, employing both (1)H MRS and mDixon.<br />Conclusion: The novel and fast two-point mDixon exhibits a good correlation with the gold-standard (1)H MRS for assessment of HFF and PFF, with limited sensitivity for assessing lower fat content.
- Subjects :
- Abdominal Fat anatomy & histology
Female
Healthy Volunteers
Humans
Magnetic Resonance Imaging methods
Male
Middle Aged
Subcutaneous Fat anatomy & histology
Whole Body Imaging
Adipose Tissue anatomy & histology
Liver anatomy & histology
Magnetic Resonance Spectroscopy methods
Pancreas anatomy & histology
Subjects
Details
- Language :
- English
- ISSN :
- 1352-8661
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Magma (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 24306514
- Full Text :
- https://doi.org/10.1007/s10334-013-0421-4