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Notch2 transduction by feline leukemia virus in a naturally infected cat.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2014 Apr; Vol. 76 (4), pp. 553-7. Date of Electronic Publication: 2013 Dec 09. - Publication Year :
- 2014
-
Abstract
- Feline leukemia virus (FeLV) induces neoplastic and nonneoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of a reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Cats
Cloning, Molecular
DNA Primers genetics
Female
Gene Components
Genes, env genetics
HEK293 Cells
Humans
Leukemia Virus, Feline genetics
Leukemia, Feline virology
Luciferases
Molecular Sequence Data
Polymerase Chain Reaction veterinary
Receptor, Notch2 genetics
Sequence Alignment
Sequence Analysis, DNA veterinary
Cat Diseases genetics
Cat Diseases virology
Leukemia Virus, Feline physiology
Leukemia, Feline genetics
Receptor, Notch2 metabolism
Transduction, Genetic veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 76
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 24317268
- Full Text :
- https://doi.org/10.1292/jvms.13-0344