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Activation of cathepsins B and L in mouse lymphosarcoma tissue under the effect of cyclophosphamide is associated with apoptosis induction and infiltration by mononuclear phagocytes.
Activation of cathepsins B and L in mouse lymphosarcoma tissue under the effect of cyclophosphamide is associated with apoptosis induction and infiltration by mononuclear phagocytes.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Nov; Vol. 156 (1), pp. 86-90. - Publication Year :
- 2013
-
Abstract
- We analyzed activities of lysosomal cystein cathepsins B and L in mouse LS lymphosarcoma and its drug-resistant RLS 40 strain and their correlations with the dynamics of the percentage of cells with fragmented DNA and CD14 (+) phagocytes over 3 days after cyclophosphamide injection. LS regression and inhibition of RLS 40 growth after cyclophosphamide injection were paralleled by an increase in cathepsins B and L activities in tumor tissues. The antitumor effect of cyclophosphamide associated with apoptosis intensity and protease activities were significantly higher in LS. Positive correlations between activities of cathepsins B and L and the LS tissue content of cells with fragmented DNA and CD14 (+) phagocytes and negative correlations thereof with tumor weight were detected. It seems that the increase in cathepsins B and L activities in LS tissues was caused by cyclophosphamide induction of apoptosis and depended on the level of tumor cell infiltration with mononuclear phagocytes.
- Subjects :
- Animals
DNA Fragmentation
Enzyme Activation
Lymphoma, Non-Hodgkin drug therapy
Lymphoma, Non-Hodgkin immunology
Lymphoma, Non-Hodgkin pathology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neoplasm Transplantation
Phagocytes drug effects
Antineoplastic Agents, Alkylating pharmacology
Apoptosis drug effects
Cathepsin B metabolism
Cathepsin L metabolism
Cyclophosphamide pharmacology
Lymphoma, Non-Hodgkin enzymology
Phagocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 156
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24319737
- Full Text :
- https://doi.org/10.1007/s10517-013-2284-0