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Bedside to bench: The risk of bleeding with parenteral omega-3 lipid emulsion therapy.
- Source :
-
The Journal of pediatrics [J Pediatr] 2014 Mar; Vol. 164 (3), pp. 652-4. Date of Electronic Publication: 2013 Dec 08. - Publication Year :
- 2014
-
Abstract
- Our clinical experience led us to reassess the effect of sole omega-3 lipid therapy on hemostasis. We compared thromboelastography platelet mapping in neonatal piglets given sole omega-3 lipid. We identified abnormalities in reaction time (P = .025) and the arachidonic acid pathway (P = .025). The potential for bleeding complications from parenteral omega-3 lipid emulsion therapy in high-risk infants with liver disease has been dismissed but, on the basis of this data, should be reconsidered.<br /> (Copyright © 2014 Mosby, Inc. All rights reserved.)
- Subjects :
- Animals
Blood Transfusion
Catheterization, Central Venous adverse effects
Disease Models, Animal
Emulsions administration & dosage
Fat Emulsions, Intravenous administration & dosage
Fish Oils administration & dosage
Humans
Infant
Intestinal Diseases complications
Intestinal Diseases drug therapy
Liver Diseases drug therapy
Liver Diseases etiology
Male
Phospholipids administration & dosage
Platelet Function Tests
Soybean Oil administration & dosage
Swine
Thrombelastography
Triglycerides
Fat Emulsions, Intravenous adverse effects
Fish Oils adverse effects
Hemorrhage chemically induced
Parenteral Nutrition
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 164
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 24321533
- Full Text :
- https://doi.org/10.1016/j.jpeds.2013.10.066