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Prognostic value of mutational characteristics in gastrointestinal stromal tumors: a single-center experience in 275 cases.
- Source :
-
Medical oncology (Northwood, London, England) [Med Oncol] 2014 Jan; Vol. 31 (1), pp. 819. Date of Electronic Publication: 2013 Dec 14. - Publication Year :
- 2014
-
Abstract
- The objective of this study was to investigate the impact of KIT/PDGFRA mutations on the prognosis of gastrointestinal stromal tumors (GISTs). In the present study, genotype analyses were performed based on GIST samples from 275 patients. The relationship between mutation and clinicopathological characteristics were explored. All factors were evaluated for their impacts on relapse-free survival (RFS). Briefly, the results of genotype analyses showed that mutations were identified in 258 (93.8 %) patients, and deletion was the most frequent type of mutation accounting for 47.3 % (122/258) of all mutation cases, followed by substitution (87/258, 33.7 %) and duplication (49/258, 19.0 %). Moreover, for KIT exon 11 mutation, the most frequently involved area was from codon 557 to 560. Deep analyses showed that the mutation types were correlated with tumor location (P = 0.005), tumor size (P = 0.022), mitosis rate (P < 0.001), risk grade (P < 0.001), and relapse (P = 0.004). Furthermore, delW557-K558 correlated with mitosis rate (P = 0.042) and relapse (P = 0.036), and delTyr568/570 correlated with tumor origin (P = 0.018). Most importantly, mitotic rate [HR = 2.901 (95 % CI 1.094-7.695), P = 0.032] and risk grade [HR = 9.629 (95 % CI 1.997-46.416), P = 0.005] would be the representative traditional prognostic factors, and deletion with >3 codons would be an novel independent predictor of poor outcome for RFS in GIST patients with deletion mutation of KIT exon 11 [HR = 7.970 (95 % CI 1.774-35.803), P = 0.007]. All results indicated that mutation determined clinicopathological features and prognosis of GISTs, and more than three codons involvement may be a novel adverse indicator.
- Subjects :
- Adult
Aged
Aged, 80 and over
Codon
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Gastrointestinal Stromal Tumors diagnosis
Genotype
Humans
Male
Middle Aged
Mitosis
Neoplasm Recurrence, Local genetics
Prognosis
Recurrence
Risk
Stomach Neoplasms diagnosis
DNA Mutational Analysis
Gastrointestinal Stromal Tumors genetics
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1559-131X
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medical oncology (Northwood, London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24338275
- Full Text :
- https://doi.org/10.1007/s12032-013-0819-x