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Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.
- Source :
-
Schizophrenia bulletin [Schizophr Bull] 2014 Nov; Vol. 40 (6), pp. 1509-17. Date of Electronic Publication: 2013 Dec 17. - Publication Year :
- 2014
-
Abstract
- Unlabelled: Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated.<br />Methods: We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP.<br />Results: Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% CI: 1.11-1.68; P < .001). Those who had started cannabis at age 15 or younger had an earlier onset of psychosis (mean years = 27.0, SD = 6.2; median years = 26.9) than those who had started after 15 years (mean years = 29.1, SD = 8.5; median years = 27.8; HR = 1.40; 95% CI: 1.06-1.84; P = .050). Importantly, subjects who had been using high-potency cannabis (skunk-type) every day had the earliest onset (mean years = 25.2, SD = 6.3; median years = 24.6) compared to never users among all the groups tested (HR = 1.99; 95% CI: 1.50- 2.65; P < .0001); these daily users of high-potency cannabis had an onset an average of 6 years earlier than that of non-cannabis users.<br />Conclusions: Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users.<br /> (© The Author 2013. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Details
- Language :
- English
- ISSN :
- 1745-1701
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Schizophrenia bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 24345517
- Full Text :
- https://doi.org/10.1093/schbul/sbt181