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KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.
- Source :
-
PloS one [PLoS One] 2013 Dec 12; Vol. 8 (12), pp. e82194. Date of Electronic Publication: 2013 Dec 12 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, KIAA1462, a gene associated with coronary artery disease, and "rokimi", encoding an untranslated spliced RNA The genetic architecture at this locus suggests that the gene product important in this association is either "rokimi", or a different isoform of KIAA1462 than the isoform that is important in cardiovascular disease. Expression data suggests that isoform f of KIAA1462 is a more attractive candidate for association with LOAD in APOE4 carriers than "rokimi" which had no detectable expression in brain.
- Subjects :
- Alleles
Brain metabolism
Brain pathology
Chromosomes, Human, Pair 10 genetics
Databases, Genetic
Exons genetics
Female
Gene Expression Regulation
Genetic Loci
Genome, Human genetics
Heterozygote
Humans
Introns genetics
Linkage Disequilibrium genetics
Lod Score
Male
Polymorphism, Single Nucleotide genetics
RNA isolation & purification
Real-Time Polymerase Chain Reaction
Alzheimer Disease genetics
Apolipoprotein E4 genetics
Cell Adhesion Molecules genetics
Coronary Artery Disease genetics
Genetic Association Studies
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 24349219
- Full Text :
- https://doi.org/10.1371/journal.pone.0082194