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[Pharmacokinetics of genistein in urine of healthy volunteers].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2013 Sep; Vol. 48 (9), pp. 1471-4. - Publication Year :
- 2013
-
Abstract
- In order to study the excretion of genistein (GEN) capsule, an estrogen drugs, in human, 30 healthy volunteers were selected and orally administered 50, 100, and 300 mg genistein in an parallel study. Genistein were determined in urine by LC-MS/MS and glucuronidated genistein (GENG) were indirectly determined with enzymatic hydrolysis in urine by LC-MS/MS, and the pharmacokinetic parameters were analyzed by DAS software (ver 2.0). The result showed that the concentrations of genistein in human urine were less than 1% of the GENG, and the cumulative excretion of GEN in 48 h were 0.037, 0.134, and 0.142 mg, separately, and the urinary excretion percentage were only 0.07%, 0.13%, and 0.05%, separately. But the cumulative excretion of GENG in 48 h was 5.3, 13.8, and 15.4 mg, separately, and the urinary excretion percentage were 10.6%, 13.8%, and 5.1%, separately, and the max urinary excretive rate was 0.4, 1.0, and 1.4 mg x h(-1), separately (tmax were 6 h). Studies showed that part of drug excreted through kidney in a form of GENG in human, and the cumulative urinary excretion and the maximum excretion rate of GENG showed a proportional increase conditioned with the dose in the range of 50-100 mg, but showed non-linear increase feature in 300 mg.
- Subjects :
- Administration, Oral
Adult
Anticarcinogenic Agents administration & dosage
Anticarcinogenic Agents urine
Chromatography, Liquid
Female
Genistein administration & dosage
Genistein urine
Glucuronides urine
Healthy Volunteers
Humans
Male
Phytoestrogens administration & dosage
Phytoestrogens urine
Tandem Mass Spectrometry
Young Adult
Anticarcinogenic Agents pharmacokinetics
Genistein pharmacokinetics
Phytoestrogens pharmacokinetics
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 48
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 24358783