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Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe.
- Source :
-
British journal of haematology [Br J Haematol] 2014 Mar; Vol. 164 (6), pp. 804-10. Date of Electronic Publication: 2013 Dec 23. - Publication Year :
- 2014
-
Abstract
- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises 7-8% of B-cell lymphomas and commonly originates from a background of long-standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of MALT lymphoma. For pulmonary MALT lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S rRNA gene-based approach, we have recently identified Achromobacter (Alcaligenes) xylosoxidans in eight of nine cases of pulmonary MALT lymphoma. A. xylosoxidans is a gram-negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with A. xylosoxidans, 124 cases of pulmonary MALT lymphoma and 82 control tissues from six European countries were analysed using a specific nested PCR. Although prevalence rates for A. xylosoxidans varied significantly from country to country, they were consistently higher for MALT lymphoma as compared to controls. Overall, 57/124 (46%) pulmonary MALT lymphomas and 15/82 (18%) control tissues were positive for A. xylosoxidans (P = 0·004). Whether the significant association of A. xylosoxidans with pulmonary MALT lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies.<br /> (© 2013 John Wiley & Sons Ltd.)
- Subjects :
- Achromobacter denitrificans genetics
Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Europe epidemiology
Female
Gram-Negative Bacterial Infections microbiology
Humans
Lymphoma, B-Cell, Marginal Zone pathology
Male
Middle Aged
Prevalence
Young Adult
Achromobacter denitrificans isolation & purification
Gram-Negative Bacterial Infections epidemiology
Gram-Negative Bacterial Infections pathology
Lymphoma, B-Cell, Marginal Zone epidemiology
Lymphoma, B-Cell, Marginal Zone microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 164
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 24372375
- Full Text :
- https://doi.org/10.1111/bjh.12703