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Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats.
- Source :
-
Molecular and cellular biochemistry [Mol Cell Biochem] 2014 Apr; Vol. 389 (1-2), pp. 35-41. Date of Electronic Publication: 2014 Jan 05. - Publication Year :
- 2014
-
Abstract
- This study was designed to determine chronic effect of high sucrose low magnesium (HSLM) diet in weanling rats on plasma thyroid profile, catecholamines and activities of key hepatic glycolytic, and gluconeogenic enzymes. Compared to control diet fed group, significantly elevated levels of plasma triiodothyronine, tetraiodothyronine, catecholamines (epinephrine, norepinephrine, and dopamine) and activity of hepatic glycolytic (hexokinase and glucokinase), and gluconeogenic (glucose-6-phosphatase) enzymes were observed in high sucrose and low magnesium fed groups. However, HSLM diet had an additive effect on all these three parameters. The study thus, assumes significance as it shows that hormonal imbalance and disorders in carbohydrate metabolism at an early stage of development can be due to dietary modification or due to deficiency of key element magnesium.
- Subjects :
- Animal Feed
Animals
Catecholamines blood
Catecholamines metabolism
Diet methods
Glucokinase blood
Glucokinase metabolism
Glucose-6-Phosphatase blood
Glucose-6-Phosphatase metabolism
Glycolysis
Hexokinase blood
Hexokinase metabolism
Liver enzymology
Liver metabolism
Male
Rats
Rats, Wistar
Triiodothyronine blood
Triiodothyronine metabolism
Carbohydrate Metabolism physiology
Dietary Carbohydrates metabolism
Hormones metabolism
Magnesium metabolism
Sucrose metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4919
- Volume :
- 389
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Molecular and cellular biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24390085
- Full Text :
- https://doi.org/10.1007/s11010-013-1924-z