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[A case of neuroendocrine carcinoma of the anal canal with multiple bone metastases successfully treated with combined modality therapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2013 Nov; Vol. 40 (12), pp. 2017-9. - Publication Year :
- 2013
-
Abstract
- Neuroendocrine carcinoma (NEC) of the anal canal is a comparatively rare tumor with a poor prognosis. We report herein a case of NEC of the anal canal with multiple bone metastases that was successfully treated with combined therapy. A 63-year-old man was referred to our hospital with the chief complaint of anal and back pain. A tumor was found in the anal canal, and pathologic examination revealed it to be NEC( Ki-67 expression>50%); fluorodeoxyglucose( FDG) positron emission tomography (PET)-computed tomography (CT) showed multiple bone metastases. Initially, a l-leucovorin/5- fluorouraci(l 5-FU)/oxaliplatin( L-OHP)(: mFOLFOX6)/bevacizumab( Bmab) regimen and octreotide were administered to treat the unresectable and advanced NEC. Strontium-89 and zoledronate were used to treat pain related to the bone metastases. After 3 months, the tumor and bone metastases became difficult to identify. The patient experienced grade 2 neurotoxicity after 5 months, and thus, we stopped L-OHP administration. After 10 months, we reintroduced L-OHP because of additional progression of the bone metastases.
- Subjects :
- Anus Neoplasms diagnostic imaging
Anus Neoplasms pathology
Bone Neoplasms diagnostic imaging
Bone Neoplasms secondary
Carcinoma, Neuroendocrine diagnostic imaging
Disease Progression
Humans
Male
Middle Aged
Positron-Emission Tomography
Tomography, X-Ray Computed
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Anus Neoplasms drug therapy
Bone Neoplasms drug therapy
Carcinoma, Neuroendocrine drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 40
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 24393998