Back to Search
Start Over
Regulatory GTP-binding proteins: emerging concepts on their role in cell function.
- Source :
-
Life sciences [Life Sci] 1987 Jul 20; Vol. 41 (3), pp. 251-8. - Publication Year :
- 1987
-
Abstract
- The last few years have evidenced a tremendous expansion in our appreciation of the role of regulatory GTP-binding proteins in cellular activation. The availability of cholera and pertussis toxins to detect G proteins as well as methodological advances in the study of cellular function has afforded the opportunity to examine G protein participation in many cellular events. Regulation of adenylyl cyclase and cyclic GMP phosphodiesterase by G proteins has been demonstrated. Phosphatidylinositol-4,5-biphosphate specific phospholipase C activity appears to be subject to G protein control. G proteins regulate inward K+ and Ca2+ channels through a mechanism which may be independent of effects on the above mentioned enzymes. Certainly, the number of G proteins which have been identified from sequencing of complementary DNA affords the potential for G protein involvement in many cellular events. Only three G proteins have however been isolated and functionally characterized, Gs, Gi and transducin. Whether all the functions of these proteins have been identified remains to be seen.
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 2439867
- Full Text :
- https://doi.org/10.1016/0024-3205(87)90146-9