Back to Search
Start Over
Biomechanics of cell adhesion: how force regulates the lifetime of adhesive bonds at the single molecule level.
- Source :
-
Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2014 Feb 14; Vol. 16 (6), pp. 2211-23. - Publication Year :
- 2014
-
Abstract
- Cell adhesion proteins play critical roles in positioning cells during development, segregating cells into distinct tissue compartments and in maintaining tissue integrity. The principle function of these proteins is to bind cells together and resist mechanical force. Adhesive proteins also enable migrating cells to adhere and roll on surfaces even in the presence of shear forces exerted by fluid flow. Recently, several experimental and theoretical studies have provided quantitative insights into the physical mechanisms by which adhesion proteins modulate their unbinding kinetics in response to tensile force. This perspective reviews these biophysical investigations. We focus on single molecule studies of cadherins, selectins, integrins, the von Willebrand factor and FimH adhesion proteins; the effect of mechanical force on the lifetime of these interactions has been extensively characterized. We review both theoretical models and experimental investigations and discuss future directions in this exciting area of research.
- Subjects :
- Adhesins, Escherichia coli metabolism
Animals
Biomechanical Phenomena
Computer Simulation
Escherichia coli cytology
Fimbriae Proteins metabolism
Humans
Models, Biological
Models, Molecular
Stress, Mechanical
von Willebrand Factor metabolism
Bacterial Adhesion
Cell Adhesion
Cell Adhesion Molecules metabolism
Escherichia coli metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1463-9084
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Physical chemistry chemical physics : PCCP
- Publication Type :
- Academic Journal
- Accession number :
- 24419646
- Full Text :
- https://doi.org/10.1039/c3cp53963f