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Immune response to influenza A(H1N1)v in HIV-infected patients.
- Source :
-
Journal of infection in developing countries [J Infect Dev Ctries] 2014 Jan 15; Vol. 8 (1), pp. 101-9. Date of Electronic Publication: 2014 Jan 15. - Publication Year :
- 2014
-
Abstract
- Introduction: HIV infection is considered a risk factor for severe outcomes of influenza A(H1N1)v infection. However, data on immune response against influenza A(H1N1)v virus in HIV-infected patients are lacking.<br />Methodology: Data from seven HIV-positive and 14 HIV-negative patients infected with A(H1N1)v and from 23 HIV-positive and six HIV-negative asymptomatic controls were analyzed to evaluate the clinical picture, A(H1N1)v viral shedding, and the immune response against the virus.<br />Results: Patients displayed mainly upper respiratory tract diseases (57.1%), while pneumonia was diagnosed only in HIV-negative patients (23.8% of subjects, of which 4.8% required intensive care unit admission). At day seven, 29% of HIV-infected patients were still positive for A(H1N1)v by RT-PCR on nasopharyngeal swabs. Interestingly, a persistence of CXCL10 secretion at high level and lower IL-6 levels was observed in HIV-positive subjects. The geometric mean haemagglutination inhibition titer (HI-GMT) and anti-influenza IgM levels were lower in HIV-positive individuals while anti-influenza IgG levels remained similar in the two groups.<br />Conclusions: The immune impairment due to HIV infection could affect A(H1N1)v clearance and could lead to a lower antibody response and a persistent secretion of CXCL10 at high levels. However, the lower IL-6 secretion and treatment with highly active antiretroviral therapy (HAART) could result in a milder clinical picture.
- Subjects :
- Adolescent
Adult
Antibodies, Viral blood
Chemokine CXCL10 blood
Female
Hemagglutination Inhibition Tests
Humans
Immunoglobulin G blood
Immunoglobulin M blood
Influenza, Human virology
Interleukin-6 blood
Male
Middle Aged
Prospective Studies
Virus Shedding
HIV Infections complications
Influenza A Virus, H1N1 Subtype immunology
Influenza, Human immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1972-2680
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of infection in developing countries
- Publication Type :
- Academic Journal
- Accession number :
- 24423719
- Full Text :
- https://doi.org/10.3855/jidc.3147