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Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburn.
- Source :
-
Neurogastroenterology and motility [Neurogastroenterol Motil] 2014 Apr; Vol. 26 (4), pp. 546-55. Date of Electronic Publication: 2014 Jan 17. - Publication Year :
- 2014
-
Abstract
- Background: Recently, it has been suggested that low esophageal basal impedance may reflect impaired mucosal integrity and increased acid sensitivity. We aimed to compare baseline impedance levels in patients with heartburn and pathophysiological characteristics related to functional heartburn (FH) divided into two groups on the basis of symptom relief after proton pump inhibitors (PPIs).<br />Methods: Patients with heartburn and negative endoscopy were treated with esomeprazole or pantoprazole 40 mg daily for 8 weeks. According to MII-pH (off therapy) analysis, patients with normal acid exposure time (AET), normal reflux number, and lack of association between symptoms and refluxes were selected; of whom 30 patients with a symptom relief higher than 50% after PPIs composed Group A, and 30 patients, matched for sex and age, without symptom relief composed Group B. A group of 20 healthy volunteers (HVs) was enrolled. For each patient and HV, we evaluated the baseline impedance levels at channel 3, during the overnight rest, at three different times.<br />Key Results: Group A (vs Group B) showed an increase in the following parameters: mean AET (1.4 ± 0.8% vs 0.5 ± 0.6%), mean reflux number (30.4 ± 8.7 vs 24 ± 6.9), proximal reflux number (11.1 ± 5.2 vs 8.2 ± 3.6), acid reflux number (17.9 ± 6.1 vs 10.7 ± 6.9). Baseline impedance levels were lower in Group A than in Group B and in HVs (p < 0.001).<br />Conclusions & Inferences: Evaluating baseline impedance levels in patients with heartburn and normal AET could achieve a better understanding of pathophysiology in reflux disease patients, and could improve the distinction between FH and hypersensitive esophagus.<br /> (© 2014 John Wiley & Sons Ltd.)
- Subjects :
- 2-Pyridinylmethylsulfinylbenzimidazoles therapeutic use
Electric Impedance
Esomeprazole therapeutic use
Esophageal pH Monitoring
Female
Gastroesophageal Reflux drug therapy
Heartburn drug therapy
Humans
Male
Middle Aged
Pantoprazole
Proton Pump Inhibitors therapeutic use
Esophagus physiopathology
Gastroesophageal Reflux physiopathology
Heartburn physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2982
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurogastroenterology and motility
- Publication Type :
- Academic Journal
- Accession number :
- 24433456
- Full Text :
- https://doi.org/10.1111/nmo.12299