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Prospective trial of customized adherence enhancement plus long-acting injectable antipsychotic medication in homeless or recently homeless individuals with schizophrenia or schizoaffective disorder.
- Source :
-
The Journal of clinical psychiatry [J Clin Psychiatry] 2013 Dec; Vol. 74 (12), pp. 1249-55. - Publication Year :
- 2013
-
Abstract
- Background: Treatment nonadherence in people with schizophrenia is associated with relapse and homelessness. Building on the usefulness of long-acting medication and our work in psychosocial interventions to enhance adherence, we conducted a prospective uncontrolled trial of customized adherence enhancement (CAE) plus long-acting injectable antipsychotic (LAI) using haloperidol decanoate in 30 homeless or recently homeless individuals with DSM-IV-defined schizophrenia or schizoaffective disorder.<br />Method: Participants received monthly CAE and LAI (CAE-L) for 6 months. Primary outcomes were adherence, as measured by the Tablets Routine Questionnaire, and housing status. Secondary outcomes included psychiatric symptoms, functioning, side effects, and hospitalizations. The study was conducted from July 2010 to December 2012.<br />Results: The mean age of participants was 41.8 years (SD = 8.6); they were mainly minorities (90%, n = 27 African-American) and mainly single/never married (70%, n = 21). Most (97%, n = 29) had past or current substance abuse and had been incarcerated (97%, n = 29). Ten individuals (33%) terminated the study prematurely. CAE-L was associated with good adherence to LAI (at 6 months, 76%) and dramatic improvement in oral medication adherence, which changed from missing 46% of medication at study enrollment to missing only 10% at study end (P = .03). There were significant improvements in psychiatric symptoms (P < .001) and functioning (P < .001). Akathisia was a major side effect with LAI.<br />Conclusions: While interpretation of findings must be tempered by the methodological limitations, CAE-L appears to be associated with improved adherence, symptoms, and functioning in homeless or recently homeless individuals with schizophrenia or schizoaffective disorder. Additional research is needed on effective and practical approaches to improving health outcomes for homeless people with serious mental illness.<br />Trial Registration: ClinicalTrials.gov identifier: NCT01152697.<br /> (© Copyright 2013 Physicians Postgraduate Press, Inc.)
- Subjects :
- Adult
Akathisia, Drug-Induced etiology
Antipsychotic Agents administration & dosage
Antipsychotic Agents adverse effects
Antipsychotic Agents pharmacokinetics
Delayed-Action Preparations administration & dosage
Delayed-Action Preparations adverse effects
Delayed-Action Preparations pharmacokinetics
Female
Haloperidol administration & dosage
Haloperidol adverse effects
Haloperidol pharmacokinetics
Hospitalization statistics & numerical data
Humans
Injections, Intramuscular
Male
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders diagnosis
Psychotic Disorders psychology
Schizophrenia diagnosis
Schizophrenic Psychology
Treatment Outcome
United States
Haloperidol analogs & derivatives
Ill-Housed Persons psychology
Medication Adherence psychology
Medication Adherence statistics & numerical data
Psychological Techniques
Psychotic Disorders drug therapy
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1555-2101
- Volume :
- 74
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of clinical psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 24434094
- Full Text :
- https://doi.org/10.4088/JCP.12m08331