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Small Ubiquitin-like Modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin.
- Source :
-
Developmental cell [Dev Cell] 2014 Jan 13; Vol. 28 (1), pp. 102-10. - Publication Year :
- 2014
-
Abstract
- Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins. GA binding to its receptor GID1 enables association of GID1 with DELLAs. This leads to the ubiquitin-mediated proteasomal degradation of DELLAs and consequently growth promotion. We report that DELLA-dependent growth control can be regulated independently of GA. We demonstrate that when a proportion of DELLAs is conjugated to the Small Ubiquitin-like Modifier (SUMO) protein, the extent of conjugation increases during stress. We identify a SUMO-interacting motif in GID1 and demonstrate that SUMO-conjugated DELLA binds to this motif in a GA-independent manner. The consequent sequestration of GID1 by SUMO-conjugated DELLAs leads to an accumulation of non-SUMOylated DELLAs, resulting in beneficial growth restraint during stress. We conclude that plants have developed a GA-independent mechanism to control growth.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Arabidopsis genetics
Arabidopsis growth & development
Arabidopsis Proteins chemistry
Arabidopsis Proteins genetics
Binding Sites
Molecular Sequence Data
Receptors, Cell Surface chemistry
Receptors, Cell Surface genetics
Receptors, Cell Surface metabolism
Repressor Proteins chemistry
Repressor Proteins genetics
SUMO-1 Protein genetics
Stress, Physiological
Arabidopsis metabolism
Arabidopsis Proteins metabolism
Gibberellins metabolism
Repressor Proteins metabolism
SUMO-1 Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1551
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Developmental cell
- Publication Type :
- Academic Journal
- Accession number :
- 24434138
- Full Text :
- https://doi.org/10.1016/j.devcel.2013.12.004