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New nitrogenous bisabolene-type sesquiterpenes from a formosan sponge Axinyssa sp.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2014; Vol. 62 (4), pp. 392-4. Date of Electronic Publication: 2014 Jan 17. - Publication Year :
- 2014
-
Abstract
- Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Cell Line, Tumor drug effects
Drug Screening Assays, Antitumor
Humans
K562 Cells drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Sesquiterpenes isolation & purification
Sesquiterpenes pharmacology
Antineoplastic Agents chemistry
Porifera chemistry
Sesquiterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5223
- Volume :
- 62
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 24441415
- Full Text :
- https://doi.org/10.1248/cpb.c13-00851