One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions.

Authors :: Sumino S
Fusano A
Okai H
Fukuyama T
Ryu I
Source :: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2014 Jan 14; Vol. 10, pp. 150-4. Date of Electronic Publication: 2014 Jan 14 (Print Publication: 2014).
Publication Year :: 2014
Abstract: The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

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