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[Effect of the steroid molecule structure on the direction of its hydroxylation by the fungus Curvularia lunata].
- Source :
-
Prikladnaia biokhimiia i mikrobiologiia [Prikl Biokhim Mikrobiol] 2013 Jul-Aug; Vol. 49 (4), pp. 382-90. - Publication Year :
- 2013
-
Abstract
- The main and side products of hydroxylation by the C. lunata VKPM F-981 mycelium of fourteen delta(4)-3-ketosteroids of the estrane, androstane, and pregnane series and six of their delta(5)-3beta-hydroxy analogues were identified by H1 PMR spectroscopy and comparison with standard samples. The obtained experimental data are considered in terms of the triangular model of the enzyme-substrate interaction. The dependence of the direction of hydroxylation of steroid molecules and the orientation of hydroxy groups on the structure of the initial substrate was revealed.
- Subjects :
- Chromatography, Liquid
Electron Spin Resonance Spectroscopy
Hydroxylation
Molecular Structure
Reference Standards
Substrate Specificity
Androstanes metabolism
Estranes metabolism
Fungal Proteins metabolism
Ketosteroids metabolism
Mycelium metabolism
Pregnanes metabolism
Saccharomycetales metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0555-1099
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Prikladnaia biokhimiia i mikrobiologiia
- Publication Type :
- Academic Journal
- Accession number :
- 24455864
- Full Text :
- https://doi.org/10.7868/s055510991304003x