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The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.
- Source :
-
Leukemia research [Leuk Res] 2014 Mar; Vol. 38 (3), pp. 340-5. Date of Electronic Publication: 2013 Dec 25. - Publication Year :
- 2014
-
Abstract
- The adaptor protein linker activator of T-cells 2 (LAT2) is a known AML1/ETO target gene whose function during normal hematopoiesis is unknown. We addressed the role of LAT2 during erythroid and myeloid differentiation of normal human CD34+ hematopoietic cells. LAT2 is expressed at low levels in CD34+ cells and upregulated during cytokine-induced myeloid and erythroid differentiation. Forced LAT2 expression leads to a delay of erythroid and myeloid differentiation keeping CD34+ cells in a more immature state, whereas LAT2 knockdown accelerates differentiation. It is tempting to speculate that by affecting the differentiation capacity of normal hematopoietic progenitors, LAT2 may contribute to the pathogenesis of AML.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adaptor Proteins, Signal Transducing antagonists & inhibitors
Adaptor Proteins, Signal Transducing immunology
Antigens, CD34 genetics
Antigens, CD34 immunology
Cell Differentiation drug effects
Cells, Cultured
Core Binding Factor Alpha 2 Subunit immunology
Gene Expression Regulation
Granulocyte-Macrophage Colony-Stimulating Factor pharmacology
Granulocytes cytology
Granulocytes drug effects
Granulocytes immunology
Hematopoietic Stem Cells cytology
Hematopoietic Stem Cells immunology
Humans
Interleukin-3 pharmacology
Leukocytes, Mononuclear
Lymphocyte Activation
Lymphocytes cytology
Lymphocytes drug effects
Lymphocytes immunology
Monocytes cytology
Monocytes drug effects
Monocytes immunology
Proto-Oncogene Proteins immunology
RNA, Small Interfering genetics
RNA, Small Interfering metabolism
RUNX1 Translocation Partner 1 Protein
Signal Transduction
Stem Cell Factor pharmacology
Transcription Factors immunology
Adaptor Proteins, Signal Transducing genetics
Core Binding Factor Alpha 2 Subunit genetics
Hematopoietic Stem Cells drug effects
Proto-Oncogene Proteins genetics
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5835
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Leukemia research
- Publication Type :
- Academic Journal
- Accession number :
- 24456692
- Full Text :
- https://doi.org/10.1016/j.leukres.2013.12.014