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Exosomes: an overview of biogenesis, composition and role in ovarian cancer.
- Source :
-
Journal of ovarian research [J Ovarian Res] 2014 Jan 25; Vol. 7, pp. 14. Date of Electronic Publication: 2014 Jan 25. - Publication Year :
- 2014
-
Abstract
- Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such as cancer. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, microRNAs and small RNAs that are representative to their cellular origin and shuttle from a donor cell to a recipient cell. From intercellular communication to tumor proliferation, exosomes carry out a diverse range of functions, both helpful and harmful. Useful as biomarkers, exosomes may be applicable in diagnostic assessments as well as cell-free anti-tumor vaccines. Exosomes of ovarian cancer contain different set of proteins and miRNAs compared to exosomes of normal, cancer-free individuals. These molecules may be used as multiple "barcode" for the development of a diagnostic tool for early detection of ovarian cancer.
- Subjects :
- Animals
Biomarkers, Tumor genetics
Exosomes immunology
Exosomes pathology
Female
Humans
MicroRNAs genetics
Molecular Targeted Therapy
Neoplasm Proteins genetics
Neoplasm Proteins immunology
Ovarian Neoplasms genetics
Ovarian Neoplasms immunology
Ovarian Neoplasms pathology
Ovarian Neoplasms therapy
Predictive Value of Tests
Signal Transduction
Tumor Escape
Biomarkers, Tumor metabolism
Exosomes metabolism
MicroRNAs metabolism
Neoplasm Proteins metabolism
Ovarian Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1757-2215
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of ovarian research
- Publication Type :
- Academic Journal
- Accession number :
- 24460816
- Full Text :
- https://doi.org/10.1186/1757-2215-7-14