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Therapy-related acute myeloid leukemia and myelodysplastic syndromes in patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group.
- Source :
-
Blood [Blood] 2014 Mar 13; Vol. 123 (11), pp. 1658-64. Date of Electronic Publication: 2014 Jan 29. - Publication Year :
- 2014
-
Abstract
- Therapy-related acute myeloid leukemia and myelodysplastic syndromes (t-AML/MDS) represent severe late effects in patients treated for Hodgkin lymphoma (HL). Because more recent data are scarce, we retrospectively analyzed incidence, outcome, and risk factors for the development of t-AML/MDS after HL. A total of 11,952 patients treated for newly diagnosed HL within German Hodgkin Study Group trials between 1993 and 2009 were considered. At a median follow-up of 72 months, t-AML/MDS was diagnosed in 106/11,952 patients (0.9%). Median time from HL treatment to t-AML/MDS was 31 months. The median age of patients with t-AML/MDS was higher than in the whole patient group (43 vs 34 years, P < .0001). Patients who received 4 or more cycles of BEACOPP(escalated) had an increased risk to develop t-AML/MDS when compared with patients treated with less than 4 cycles of BEACOPP(escalated) or no BEACOPP chemotherapy (1.7% vs 0.7% vs 0.3%, P < .0001). The median overall survival (OS) for all t-AML/MDS patients was 7.2 months. However, t-AML/MDS patients proceeding to allogeneic stem cell transplantation had a significantly better outcome with a median OS not reached after a median follow-up of 41 months (P < .001).
- Subjects :
- Adolescent
Adult
Aged
Bleomycin adverse effects
Cyclophosphamide adverse effects
Doxorubicin adverse effects
Etoposide adverse effects
Female
Follow-Up Studies
Germany
Hodgkin Disease pathology
Humans
Incidence
Leukemia, Myeloid, Acute mortality
Male
Middle Aged
Myelodysplastic Syndromes mortality
Prednisone adverse effects
Procarbazine adverse effects
Prognosis
Retrospective Studies
Survival Rate
Vincristine adverse effects
Young Adult
Antineoplastic Combined Chemotherapy Protocols adverse effects
Hematopoietic Stem Cell Transplantation
Hodgkin Disease drug therapy
Leukemia, Myeloid, Acute chemically induced
Myelodysplastic Syndromes chemically induced
Neoplasms, Second Primary
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 123
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 24478403
- Full Text :
- https://doi.org/10.1182/blood-2013-07-512657