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[Study on miR-490-5p and miR-363 as novel biomarkers for the diagnosis of colorectal cancer].
- Source :
-
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery [Zhonghua Wei Chang Wai Ke Za Zhi] 2014 Jan; Vol. 17 (1), pp. 45-50. - Publication Year :
- 2014
-
Abstract
- Objective: To identify dysregulated microRNA(miRNA) that can act as novel biomarker for colorectal cancer screening.<br />Methods: Real time-polymerase chain reaction was used to detect the expression profile of miRNA in tumor and paired normal tissues, and the significant dysregulated miRNA was examined by non-paired t-test. Receiver operating characteristic(ROC) curve was performed to evaluate the specificity and sensitivity of miR-363 and miR-490-5p as biomarkers to discriminate colorectal cancer patients from normal person.<br />Results: Seven-three dysregulated miRNAs were found in male samples, of which 6 miRNAs were up-regulated and other 67 miRNAs were down-regulated, while 42 dysregulated miRNAs were found in female samples, of which 5 were up-regulated and 37 were down-regulated in tumor tissues compared with normal tissues. Among above dysregulated miRNAs, 33 miRNAs had significant differences, besides, dysregulated expression level of 10 of 33 miRNAs was over 5 folds in male and female as well as mixed samples.<br />Conclusions: The expression pattern in female is different from that in male. miR-363 and miR-490-5p possess the potential in screening colorectal cancer patients from healthy people.
Details
- Language :
- Chinese
- ISSN :
- 1671-0274
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
- Publication Type :
- Academic Journal
- Accession number :
- 24519049