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The direct and indirect impact of comorbidity on the survival of patients with non-small cell lung cancer: a combination of survival, staging and resection models with missing measurements in covariates.
- Source :
-
BMJ open [BMJ Open] 2014 Feb 12; Vol. 4 (2), pp. e003846. Date of Electronic Publication: 2014 Feb 12. - Publication Year :
- 2014
-
Abstract
- Objective: To examine the direct and indirect impact of comorbidity on the survival.<br />Design: A historical cohort study.<br />Setting: Denmark.<br />Participants: All patients with non-small cell lung cancer who were registered in the Danish Lung Cancer Registry in 2010.<br />Main Outcome Measures: The influence of comorbidity on stage misclassification, probability of resection and survival.<br />Results: It was estimated that the comorbidity influences the probability of resection with OR 0.65 and 95% credible interval (0.54; 0.79), the staging process with OR 1.08 and 95% credible interval (0.96; 1.20), and the survival process with HR 1.08 and 95% credible interval (1.02; 1.14).<br />Conclusions: We found that comorbidity has a significant indirect effect on survival mediated by the resection process and a slightly direct effect on mortality.
- Subjects :
- Aged
Carcinoma, Non-Small-Cell Lung pathology
Denmark
Female
Humans
Lung Neoplasms pathology
Male
Models, Statistical
Neoplasm Staging
Prognosis
Registries
Risk Factors
Carcinoma, Non-Small-Cell Lung mortality
Carcinoma, Non-Small-Cell Lung surgery
Comorbidity
Lung Neoplasms mortality
Lung Neoplasms surgery
Survival Analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2044-6055
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- BMJ open
- Publication Type :
- Academic Journal
- Accession number :
- 24523421
- Full Text :
- https://doi.org/10.1136/bmjopen-2013-003846