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Potential therapeutic use of herbal extracts in trypanosomiasis.
- Source :
-
Pathogens and global health [Pathog Glob Health] 2014 Jan; Vol. 108 (1), pp. 30-6. Date of Electronic Publication: 2013 Dec 19. - Publication Year :
- 2014
-
Abstract
- The aim of the present study was to evaluate the effects of crude extracts from Handroanthus impetiginosa, Ageratum conyzoides, and Ruta graveolens on Leishmania amazonensis and Trypanosoma cruzi infection in vitro. The results showed that the extracts caused significant toxicity in promastigotes and trypomastigotes. A significant decrease in the rate of cell invasion by pretreated trypomastigotes and promastigotes was also observed. The extracts caused a significant reduction of the multiplication of intracellular amastigotes of both parasites. Therefore, these herbal extracts may be potential candidates for the development of drugs for the treatment of leishmaniasis and Chagas disease.
- Subjects :
- Animals
Antigens, Surface drug effects
Asteraceae chemistry
Bignoniaceae chemistry
Female
Fluorescent Antibody Technique
Humans
Male
Neuraminidase drug effects
Protozoan Proteins drug effects
Rutaceae chemistry
Trypanosomiasis drug therapy
Variant Surface Glycoproteins, Trypanosoma drug effects
Antigens, Protozoan drug effects
Antiprotozoal Agents pharmacology
Chagas Disease drug therapy
Leishmania drug effects
Leishmaniasis drug therapy
Phytotherapy methods
Plant Preparations pharmacology
Trypanosoma cruzi drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2047-7732
- Volume :
- 108
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pathogens and global health
- Publication Type :
- Academic Journal
- Accession number :
- 24548158
- Full Text :
- https://doi.org/10.1179/2047773213Y.0000000120