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Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis.
- Source :
-
BMC cancer [BMC Cancer] 2014 Feb 18; Vol. 14, pp. 104. Date of Electronic Publication: 2014 Feb 18. - Publication Year :
- 2014
-
Abstract
- Backgrounds: Glypican-3(GPC3) has been implicated in tumor development and progression for several years. However, the prognostic significance of GPC3 expression in patients with hepatocellular carcinoma (HCC) is controversial. We performed a meta-analysis of available studies to assess whether GPC3 can be used as a prognostic factor in patients with HCC.<br />Methods: We searched PubMed and Ovid EBM Reviews databases and evaluated the reference list of relevant articles for studies that assessed the prognostic relevance of GPC3 in patients with HCC. Meta-analysis was performed using hazard ratio (HR) or odds ratio (OR) and 95% confidence intervals (95% CIs) as effect measures.<br />Results: A meta-analysis of eight studies included 1070 patients was carried out to evaluate the association between GPC3 and overall survival (OS) and disease-free survival (DFS) in HCC patients. The relation between GPC3 and tumor pathological features was also assessed. Our analysis results indicated that high GPC3 expression predicted poor OS (HR: 1.96, 95% CI: 1.51-2.55) and DFS (HR: 1.99, 95% CI: 1.57-2.51) of patients with HCC. GPC3 overexpression was significantly associated with high tumor grade (OR: 3.30, 95% CI: 2.04-5.33), late TNM stage (OR: 2.26, 95% CI: 1.00-5.12), and the presence of vascular invasion (OR: 2.43, 95% CI: 1.23-4.82).<br />Conclusions: GPC3 overexpression indicates a poor prognosis for patients with HCC, and it may also have predictive potential for HCC invasion and metastasis.
- Subjects :
- Biomarkers, Tumor biosynthesis
Carcinoma, Hepatocellular pathology
Disease-Free Survival
Gene Expression Regulation, Neoplastic
Glypicans biosynthesis
Humans
Liver Neoplasms pathology
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Carcinoma, Hepatocellular genetics
Glypicans genetics
Liver Neoplasms genetics
Prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 24548704
- Full Text :
- https://doi.org/10.1186/1471-2407-14-104