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Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2014 Jan 15; Vol. 7 (2), pp. 709-15. Date of Electronic Publication: 2014 Jan 15 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Interleukin-6 (IL-6) is one of the most important cytokines which has been shown to play a critical role in the pathogenesis of cholesteatoma. In this study, we aimed to investigate the expression of interleukin-6 (IL-6) and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in middle ear cholesteatoma epithelium in an effort to determine the role of IL-6/JAK/STAT3 signaling pathway in the pathogenesis of cholesteatoma. Immunohistochemistry was used to examine the expression of IL-6 and p-STAT3 in 25 human middle ear cholesteatoma samples and 15 normal external auditory canal (EAC) epithelium specimens. We also analyzed the relation of IL-6 and p-STAT3 expression levels to the degree of bone destruction in cholesteatoma. We found that the expression of IL-6 and p-STAT3 were significantly higher in cholesteatoma epithelium than in normal EAC epithelium (p<0.05). In cholesteatoma epithelium, a significant positive association was observed between IL-6 and p-STAT3 expression (p<0.05). However, no significant relationships were observed between the degree of bone destruction and the levels of IL-6 and p-STAT3 expression (p>0.05). To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma.
- Subjects :
- Adult
Case-Control Studies
Cell Proliferation
Cholesteatoma, Middle Ear pathology
Ear Ossicles pathology
Ear, Middle pathology
Enzyme Activation
Epithelial Cells pathology
Female
Humans
Immunohistochemistry
Male
Phosphorylation
Cholesteatoma, Middle Ear metabolism
Ear, Middle chemistry
Epithelial Cells chemistry
Interleukin-6 analysis
Janus Kinases analysis
STAT3 Transcription Factor analysis
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 24551293