Back to Search
Start Over
[Clinical evaluation on an enzyme immunoassay kit for basic fetoprotein (BFP). (1) Clinical usefulness of BFP].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1988 Jul; Vol. 15 (7), pp. 2107-13. - Publication Year :
- 1988
-
Abstract
- Clinical usefulness of a sandwich enzyme immunoassay kit for basic fetoprotein (BFP), which has been developed with two kinds of monoclonal anti-BFP by Nippon Kayaku Co., LTD., was evaluated on detection of BFP in the sera. Based on the consideration of BFP-positive rate under 5% in healthy donors and diagnostic efficiency for cancer, a BFP-concentration of 75ng/ml was used as the cut off value. BFP in the sera was positive in 3.5% of 368 healthy donors, 18.2% of 549 patients with benign diseases and 45.3% of 870 patients with cancer. High positive rates of 50 approximately 60% for the serum BFP were found in cancer of the liver, bile duct, pancreas, kidney, prostate, testis and ovary. In early cancer of the bile duct and urogenital organs, high BFP-positive rates beyond 46% were recognized. BFP values in 7 of 9 BFP-positive patients with urogenital cancer fell down to negative serum level after the radical operation. These results indicate that BFP is a tumor marker with widespread representation in cancer and contributes to serological diagnosis for cancer of digestive and urogenital systems, particularly for early cancer of these systems. Furthermore, it is suggested that BFP is useful for monitoring of cancer patients after surgery.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Monoclonal
Child
Female
Gastrointestinal Neoplasms blood
Gastrointestinal Neoplasms diagnosis
Gastrointestinal Neoplasms surgery
Humans
Immunoenzyme Techniques
Male
Middle Aged
Predictive Value of Tests
Urogenital Neoplasms blood
Urogenital Neoplasms diagnosis
Urogenital Neoplasms surgery
alpha-Fetoproteins immunology
Biomarkers, Tumor blood
Neoplasms blood
alpha-Fetoproteins analysis
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 2456039