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Metal complexes as structural templates for targeting proteins.
- Source :
-
Current opinion in chemical biology [Curr Opin Chem Biol] 2014 Apr; Vol. 19, pp. 76-81. Date of Electronic Publication: 2014 Feb 19. - Publication Year :
- 2014
-
Abstract
- This article reviews recent advances in the design and discovery of inert metal complexes as protein binders. In these metal-based probes or drug candidates, the metal is supposed to exert a purely structural role by organizing the coordinating ligands in the three dimensional space to achieve a shape and functional group complementarity with the targeted protein pockets. Presented examples of sandwich, half-sandwich and octahedral d(6)-metal complexes reinforce previous perceptions that metal complexes are highly promising scaffolds for the design of small-molecule protein binders and complement the molecular diversity of organic chemistry by opening untapped chemical space.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0402
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- Current opinion in chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 24561508
- Full Text :
- https://doi.org/10.1016/j.cbpa.2014.01.005