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Localized scleroderma and regional inflammatory myopathy.
- Source :
-
Neuromuscular disorders : NMD [Neuromuscul Disord] 2014 May; Vol. 24 (5), pp. 425-30. Date of Electronic Publication: 2014 Feb 01. - Publication Year :
- 2014
-
Abstract
- Inflammatory myopathy is rare in localized scleroderma. We report 2 new cases of regional inflammatory myopathy associated with localized scleroderma and review 10 reported cases of localized scleroderma associated with an inflammatory myopathy with regional muscle involvement, more often in the upper extremities. Serum creatine kinase was mildly elevated or normal. Histopathology often showed perimysial inflammation and plasma cell infiltration. These cases demonstrate that inflammatory myopathy should be considered in patients with localized scleroderma and regional muscle weakness, pain or atrophy. Muscle biopsy can confirm the diagnosis of myositis, which if identified, will require anti-inflammatory and/or immunosuppressive therapy.<br /> (Published by Elsevier B.V.)
- Subjects :
- Adult
Child
Creatine Kinase blood
Female
Humans
Leg
Magnetic Resonance Imaging
Male
Muscle, Skeletal pathology
Myositis blood
Myositis diagnosis
Myositis pathology
Scleroderma, Localized blood
Scleroderma, Localized diagnosis
Scleroderma, Localized pathology
Thoracic Vertebrae
Myositis complications
Scleroderma, Localized complications
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2364
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuromuscular disorders : NMD
- Publication Type :
- Academic Journal
- Accession number :
- 24569141
- Full Text :
- https://doi.org/10.1016/j.nmd.2014.01.012