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L-menthol improves adenoma detection rate during colonoscopy: a randomized trial.
- Source :
-
Endoscopy [Endoscopy] 2014 Mar; Vol. 46 (3), pp. 196-202. Date of Electronic Publication: 2014 Feb 26. - Publication Year :
- 2014
-
Abstract
- Background and Study Aims: Colonoscopy is one of the most reliable methods for the detection of colorectal neoplasms. However, colonic peristalsis during colonoscopy results in some neoplastic lesions being hidden from view and commonly requires an intravenous or intramuscular injection of antispasmodic agents, which may sometimes causes unexpected adverse reactions. The aim of this study was to evaluate the efficacy of L-menthol spray as an antiperistaltic agent and its effect on adenoma detection.<br />Patients and Methods: This was a prospective, randomized, single-blind placebo-controlled trial. A total of 226 patients who were scheduled to undergo colonoscopy were randomly assigned to receive either 20 mL of 1.6 % L-menthol (n = 118) or placebo (n = 108). Both treatments were sprayed locally onto the colonic mucosa via an endoscope. The adenoma detection rate (ADR) and the proportion of patients with no peristalsis were the primary and secondary outcomes, respectively.<br />Results: The ADR was significantly higher in the L-menthol group than in the placebo group (60.2 % vs. 42.6 %; P = 0.0083). The proportion of patients with no peristalsis after treatment with L-menthol was significantly higher than in the placebo group (71.2 % vs. 30.9 %; P < 0.0001). There were no adverse effects in either group.<br />Conclusions: The results suggest that the suppression of colonic peristalsis by L-menthol sprayed directly onto the colonic mucosa improves the ADR.<br />Clinical Trial Registration: ID: UMIN 000007972.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antidiarrheals adverse effects
Colon drug effects
Female
Humans
Intestinal Mucosa drug effects
Male
Menthol adverse effects
Middle Aged
Prospective Studies
Single-Blind Method
Adenoma diagnosis
Antidiarrheals administration & dosage
Colonic Neoplasms diagnosis
Colonoscopy methods
Menthol administration & dosage
Peristalsis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1438-8812
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 24573731
- Full Text :
- https://doi.org/10.1055/s-0034-1365035