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Experimental murine acremoniosis: an emerging opportunistic human infection.
- Source :
-
Medical mycology [Med Mycol] 2014 Jan; Vol. 52 (1), pp. 29-35. - Publication Year :
- 2014
-
Abstract
- Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 10(6) and 2 × 10(8) conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.
- Subjects :
- Animal Structures microbiology
Animal Structures pathology
Animals
Colony Count, Microbial
Communicable Diseases, Emerging epidemiology
Communicable Diseases, Emerging microbiology
Communicable Diseases, Emerging pathology
Disease Models, Animal
Histocytochemistry
Humans
Male
Mice
Microscopy
Mycoses epidemiology
Opportunistic Infections epidemiology
Opportunistic Infections microbiology
Opportunistic Infections pathology
Proteoglycans
Survival Analysis
Virulence
beta-Glucans blood
Acremonium pathogenicity
Mycoses microbiology
Mycoses pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2709
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medical mycology
- Publication Type :
- Academic Journal
- Accession number :
- 24577339
- Full Text :
- https://doi.org/10.3109/13693786.2013.797610