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Alpha-synuclein repeat variants and survival in Parkinson's disease.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2014 Jul; Vol. 29 (8), pp. 1053-7. Date of Electronic Publication: 2014 Feb 27. - Publication Year :
- 2014
-
Abstract
- Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).<br />Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.<br />Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).<br />Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.<br /> (© 2014 International Parkinson and Movement Disorder Society.)
- Subjects :
- Adult
Age of Onset
Aged
Aged, 80 and over
Female
Gene Frequency
Genetic Association Studies
Genotype
Humans
International Cooperation
Male
Middle Aged
Parkinson Disease mortality
Dinucleotide Repeats genetics
Genetic Predisposition to Disease genetics
Parkinson Disease genetics
Survival
alpha-Synuclein genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 29
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 24578302
- Full Text :
- https://doi.org/10.1002/mds.25841