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Eosinophilic inflammation of chronic rhinosinusitis with nasal polyps is related to OX40 ligand expression.
- Source :
-
Innate immunity [Innate Immun] 2015 Feb; Vol. 21 (2), pp. 167-74. Date of Electronic Publication: 2014 Feb 28. - Publication Year :
- 2015
-
Abstract
- The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic sinus infiltration. Twenty patients with chronic rhinosinusitis (11 with and nine without NPs) and seven controls were enrolled in the study. The mRNA expression of OX40 ligand and thymic stromal lymphopoietin and its receptor were analyzed. The immunoreactivity score for OX40 ligand and the eosinophil count were obtained. The mRNA expression and immunoreactivity score of OX40 ligand were higher in patients with nasal polyposis than in patients without NPs, as well as healthy controls. The mRNA expression of thymic stromal lymphopoietin and its receptor was significantly higher in nasal polyposis than in the control, but not significantly higher than in chronic rhinosinusitis without NPs. A correlation between the number of OX40 ligand-positive cells and the number of eosinophils in sinus biopsies was found only in patients with nasal polyposis. In conclusion, the thymic stromal lymphopoietin/OX40 ligand axis is up-regulated in nasal polyposis and is related to the intensity of eosinophilic inflammation.<br /> (© The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Cell Movement
Chronic Disease
Cytokines genetics
Cytokines metabolism
Female
Humans
Inflammation pathology
Male
Middle Aged
Nasal Polyps complications
OX40 Ligand genetics
Paranasal Sinuses metabolism
Paranasal Sinuses pathology
Receptors, Cytokine genetics
Receptors, Cytokine metabolism
Rhinitis complications
Sinusitis complications
Thymic Stromal Lymphopoietin
Eosinophils immunology
Nasal Polyps immunology
OX40 Ligand metabolism
Rhinitis immunology
Sinusitis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1753-4267
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Innate immunity
- Publication Type :
- Academic Journal
- Accession number :
- 24583911
- Full Text :
- https://doi.org/10.1177/1753425914523460