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Prevention of colonic spasm using L-menthol in colonoscopic examination.
- Source :
-
International journal of colorectal disease [Int J Colorectal Dis] 2014 May; Vol. 29 (5), pp. 579-83. Date of Electronic Publication: 2014 Mar 02. - Publication Year :
- 2014
-
Abstract
- Purpose: The detailed efficacy of intraluminal L-menthol for preventing colonic spasm is not known. The aim of this study was to evaluate the effectiveness of L-menthol in preventing colonic spasm during colonoscopy.<br />Methods: We analyzed 65 patients (mean age: 71.7 years; 49 men and 16 women) who were administered 0.8% L-menthol (MINCLEA, Nihon Seiyaku, Tokyo, Japan) intraluminally for severe colonic spasm during colonoscopic examination at Kyoto Prefectural University of Medicine between February 2012 and May 2013. The efficacy of L-menthol was defined as the absence of colonic spasm during a period of 30 s, and its effect was evaluated at 30 s, 1 min, and 5 min after administration. Additionally, various characteristics of these patients were analyzed. Twenty-seven patients with severe colonic spasm were administered intraluminal water and assessed as controls.<br />Results: L-Menthol was effective in preventing colonic spasms in 60.0%, 70.8%, and 46.5% of patients at 30 s, 1 min, and 5 min, respectively. In contrast, water was effective in 22.2%, 29.6%, and 48.1% of patients at 30 s, 1 min, and 5 min, respectively. There was a significant difference about the efficacy at 30 s and 1 min between L-menthol and water (Pā=ā0.0009, Pā=ā0.0006).<br />Conclusions: L-Menthol (0.8%) was effective in preventing colonic spasm during colonoscopic examination.
Details
- Language :
- English
- ISSN :
- 1432-1262
- Volume :
- 29
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of colorectal disease
- Publication Type :
- Academic Journal
- Accession number :
- 24584277
- Full Text :
- https://doi.org/10.1007/s00384-014-1844-8