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[Research advance on the role of ubiquitin proteasome pathway in acute promyelocytic leukemia].
- Source :
-
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2014 Feb; Vol. 22 (1), pp. 232-6. - Publication Year :
- 2014
-
Abstract
- Acute promyelocytic leukemia (APL) is characterized by PML-RARa expression. Ubiquitin proteasome-pathway (UPP) plays a key role in all-trans retinoid acid (ATRA) and arsenic trioxide (ATO)-induced degradation. In addition, the regulations of cell cycle and transcription are also related to this pathway. Deeply studying the role of ubiquitin-proteasome pathway in APL contributes to elucidate the mechanisms of some drugs and explode the clinical therapeutical insight for APL. In this article, the constitution of UPP, the role of UPP-mediated protein modification in APL, the application of ubiquitination-associated drugs in APL are reviewed.
Details
- Language :
- Chinese
- ISSN :
- 1009-2137
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhongguo shi yan xue ye xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 24598685
- Full Text :
- https://doi.org/10.7534/j.issn.1009-2137.2014.01.046