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Cervical mucus removal before embryo transfer in women undergoing in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials.
- Source :
-
Fertility and sterility [Fertil Steril] 2014 May; Vol. 101 (5), pp. 1302-7. Date of Electronic Publication: 2014 Mar 03. - Publication Year :
- 2014
-
Abstract
- Objective: To appraise critically the published randomized controlled trials (RCTs) reporting on the effectiveness of cervical mucus removal before embryo transfer.<br />Design: Systematic review and meta-analysis of RCTs.<br />Setting: Assisted reproduction technology (ART) units.<br />Patient(s): Women undergoing embryo transfer after in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).<br />Intervention(s): Cervical mucus removal followed or not by cervical irrigation immediately before embryo transfer.<br />Main Outcome Measure(s): Clinical pregnancy, implantation and live-birth rates.<br />Result(s): Eight RCTs involving 1,715 women were systematically analyzed. There was substantial heterogeneity among the included trials. There was no statistically significant difference in terms of pregnancy, implantation, or live-birth rates.<br />Conclusion(s): A meta-analysis from the available moderate to low quality trials provides very little evidence of an overall benefit of cervical mucus removal before embryo transfer for women undergoing IVF/ICSI. Due to problems of clinical diversity, statistical heterogeneity, and risk of bias, additional pragmatic multicenter RCTs are needed to evaluate the possible small benefit of cervical mucus removal before embryo transfer.<br /> (Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Embryo Transfer methods
Female
Fertilization in Vitro methods
Fertilization in Vitro trends
Humans
Infertility, Female embryology
Multicenter Studies as Topic methods
Multicenter Studies as Topic trends
Pregnancy
Pregnancy Rate trends
Randomized Controlled Trials as Topic methods
Sperm Injections, Intracytoplasmic methods
Cervix Mucus chemistry
Cervix Mucus metabolism
Embryo Transfer trends
Infertility, Female therapy
Randomized Controlled Trials as Topic trends
Sperm Injections, Intracytoplasmic trends
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 101
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 24602754
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2014.01.047