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Cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum attenuatum.
- Source :
-
Fitoterapia [Fitoterapia] 2014 Jun; Vol. 95, pp. 1-7. Date of Electronic Publication: 2014 Mar 03. - Publication Year :
- 2014
-
Abstract
- Six new polycyclic polyprenylated acylphloroglucinols, attenuatumiones A-F (1-6), together with twelve known analogs (7-18) were isolated from the whole plant of Hypericum attenuatum. Their structures were elucidated by spectroscopic methods, and the absolute configuration of C-13 in attenuatumione C (3) was deduced via the circular dichroism datum of the in situ formed [Rh2(OCOCF3)4] complexes. All isolates were evaluated for the cytotoxic activities on three human cancer cell lines. Compound 3 showed moderate cytotoxic activities with IC50 values of 10.12 and 10.56 μM against SMMC7721 and U2OS, respectively.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Phloroglucinol analogs & derivatives
Phloroglucinol chemistry
Phloroglucinol isolation & purification
Plant Extracts chemistry
Plant Extracts isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Hypericum chemistry
Molecular Structure
Phloroglucinol pharmacology
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 95
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 24603092
- Full Text :
- https://doi.org/10.1016/j.fitote.2014.02.011