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Simultaneous R2*, R2, and R2' quantification by combining S0 estimation of the free induction decay with a single spin echo: A single acquisition method for R2 insensitive quantification of holmium-166-loaded microspheres.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2015 Jan; Vol. 73 (1), pp. 273-83. Date of Electronic Publication: 2014 Mar 07. - Publication Year :
- 2015
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Abstract
- Purpose: To present a new method, S0 estimation of the free induction decay combined with a single spin echo measurement (SOFIDSE), that enables simultaneous measurements of R2*, R2, and R2' in order to quantify the local concentration of holmium microspheres (Ho-MS) for radioembolization.<br />Theory and Methods: SOFIDSE estimates R2* and the signal magnitude at time point 0, S0, from a multigradient echo readout of the free induction decay and subsequently estimates R2 using S0 and a single spin echo, from which R2' is deducted. The method was evaluated by comparing SOFIDSE R2 values with values obtained from shifted spin echo (SSE) measurements on a phantom setup containing Ho-MS and from dual spin echo measurements on a healthy volunteer.<br />Results: On average, SOFIDSE showed a small overestimation of R2 values compared with SSE independent of the microsphere concentration. R2' values determined by subtraction of either SOFIDSE R2 or SSE R2 from R2* showed excellent agreement (correlation coefficient = 1; P = 9 · 10(-11)). The Ho-MS-induced R2' values obtained by SOFIDSE were insensitive to the R2 value of the tissue in which they resided.<br />Conclusion: SOFIDSE enables quantification of Ho-MS, in media with spatially or temporally varying R2 values, in a single acquisition.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Capsules analysis
Capsules chemistry
Humans
Male
Microspheres
Phantoms, Imaging
Radiopharmaceuticals analysis
Reproducibility of Results
Sensitivity and Specificity
Spin Labels
Tissue Distribution
Echo-Planar Imaging methods
Holmium analysis
Image Interpretation, Computer-Assisted methods
Molecular Imaging methods
Radioisotopes analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 73
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24610772
- Full Text :
- https://doi.org/10.1002/mrm.25138